New research suggests that individuals who stop using blockbuster slimming jabs like Wegovy and Mounjaro may regain reduced body mass at a significantly accelerated pace than those who halt conventional diet and exercise plans.
Research printed in a major medical journal demonstrates that while overweight individuals often shed about a fifth of their body weight while using the jabs, the mass is regained at an average rate of 0.8 kg per month upon discontinuation.
"People using such treatments should be informed of the potential of quick rebound weight gain when the therapy concludes," warns expert Dr. Susan Jebb.
This pace of regain means a return to starting weight within about one and a half years.
Weighing Approaches
The analysis, which looked at dozens of trials involving thousands of participants, contrasted the outcomes of the injectable medications with older methods.
Scientists point out that people who lose weight through diet and exercise typically experience a more gradual weight regain—approximately 100 grams monthly—post-intervention.
Explaining the Quick Regain
Experts believe the mechanism of the drugs is key to understanding the amplified rebound.
These medications imitate a body's own chemical called glucagon-like peptide-1, which moderates appetite.
"Sustained high doses of GLP-1 concentrations several times higher than normal could lead to the body to generate a reduced amount of its endogenous hormone, and could reduce responsiveness to its actions," said Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication leads to hunger is uncontrolled, making excessive eating a significant risk."
A Chronic Disease?
Health authorities suggest the jabs for individuals with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts argue that, considering the high risk of relapse, the treatment is often life-long.
This view is reinforced by drug manufacturers, who note that the results "emphasize the chronic nature of excess weight," similar to managing conditions like hypertension.
User Accounts
People who have discontinued the jabs explain a powerful return of appetite.
"I experienced something activating and you become starving," said an individual.
The struggle is compounded if individuals have not adopted lasting lifestyle or habit modifications during therapy.
Widespread Use
Recent estimates indicate that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with desire being substantial.
- Use is greater among females compared to men.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion access the medications through private healthcare rather than the NHS.
In conclusion, researchers caution that while the jabs are potent agents for shedding pounds, they are not a standalone cure and lasting health benefits relies on ongoing behavioural changes.
